Towards the elucidation of the true impact of adipocytokines on cardiovascular risk in rheumatoid arthritis
نویسندگان
چکیده
Adipo(cyto)kines are mostly produced by adipose tissue and orchestrate the adverse impact of excess adiposity on cardiovascular risk. Adipokines also contribute importantly to the pathophysiology of rheumatoid arthritis. Congruent with data reported in previous investigations, Kang and colleagues report in this issue of Arthritis Research & Therapy that adipokine concentrations are further associated with metabolic risk and inflammation and that the leptin–adiponectin ratio associates with the carotid artery resistive index in rheumatoid arthritis. Guided by evidence reported thus far on cardiovascular risk, we discuss six reasons why careful elucidation of adipokine–cardiovascular risk relations is needed in rheumatoid arthritis
منابع مشابه
Plasma levels of leptin and visfatin in rheumatoid arthritis patients; is there any relationship with joint damage?
Objective (s):Rheumatoid arthritis (RA) is a chronic systemic inflammatory disorder, primarily targeting the synovium and articular cartilage that leads to joint damage. Recent reports have suggested the role of adipocytokines in mediating joint damage; however it still is a matter of debate. The purpose of this study was to evaluate the association between serum values of adiopocytokines (lept...
متن کاملEffects of the Teach-back Method of Self-care Education on the Pain Intensity and Sleep Quality of Rheumatoid Arthritis Patients
Background & Aims: Rheumatoid arthritis is a chronic, inflammatory, and progressive autoimmune disease with variable clinical symptoms, which could also be the main cause of disability, short life, and even death. Pain is the most common symptom of rheumatoid arthritis, which plays a key role in the pattern of sleep and rest, and approximately 80% of patients with rheumatoid arthritis complain ...
متن کاملThe Role of Perception of Pain and Functional Disability in Predicting Ruminant Intellectual Women with Rheumatoid Arthritis
Introduction Rheumatoid arthritis is the most common inflammatory disease of the joints and in addition to physical disability, mental disorders are very common in these patients. mental rumination is one of the problems that patients with rheumatoid arthritis face, and one of the factors that has a great impact on it is the perception of pain and functional dysfunction of patients. Therefore,...
متن کاملRheumatic Diseases and Obesity: Adipocytokines as Potential Comorbidity Biomarkers for Cardiovascular Diseases
Inflammation has been recognized as a common trait in the pathogenesis of multifactorial diseases including obesity, where a low-grade inflammation has been established and may be responsible for the cardiovascular risk related to the disease. Obesity has also been associated with the increased incidence and a worse outcome of rheumatoid arthritis (RA) and osteoarthritis (OA). RA is characteriz...
متن کاملCD226 rs763361 (Gly307Ser) Polymorphism Is Associated with Susceptibility to Rheumatoid Arthritis in Zahedan, Southeast Iran
Background: Rheumatoid arthritis (RA) is a chronic inflammatory disease with many genetic factors predisposing to disease susceptibility. The aim of the present study was to investigate the impact of CD226 rs727088 and rs763361 polymorphisms and susceptibility to RA in a sample of the Iranian population. Methods: This case-control study was carried out on 100 patients with RA and 104 healthy su...
متن کامل